Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history

In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and...

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Veröffentlicht in:European journal of human genetics : EJHG 2018-07, Vol.26 (7), p.972-983
Hauptverfasser: Meiser, Bettina, Quinn, Veronica F, Mitchell, Gillian, Tucker, Kathy, Watts, Kaaren J, Rahman, Belinda, Peate, Michelle, Saunders, Christobel, Geelhoed, Elizabeth, Gleeson, Margaret, Barlow-Stewart, Kristine, Field, Michael, Harris, Marion, Antill, Yoland C, Susman, Rachel, Bowen, Michael T, Mills, Llew, Kirk, Judy
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Sprache:eng
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Zusammenfassung:In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Women aged
ISSN:1018-4813
1476-5438
DOI:10.1038/s41431-017-0057-3