Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles

Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles

A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologic...

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Veröffentlicht in:Organic letters 2018-06, Vol.20 (12), p.3487-3490
Hauptverfasser: Sun, Alexandra C, McClain, Edward J, Beatty, Joel W, Stephenson, Corey R. J
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
alkylation agents
carboxylic acids
Catalysis
catalytic activity
chemical structure
Light
Molecular Structure
Oxidation-Reduction
redox reactions
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Zusammenfassung:A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologically relevant heterocyclic scaffolds under mild conditions.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.8b01250