EPEN-26. TO STUDY THE DEMOGRAPHIC CHARACTERISTICS OF PEDIATRIC EPENDYMOMA PATIENTS AND EVALUATE THE EFFICACY OF DIFFERENT TREATMENT MODALITIES AT KING FAHAD MEDICAL CITY (KFMC), RIYADH

Abstract PROCEDURES A retrospective review was performed for pediatric patients (< 14 years of age) with ependymoma who were treated at KFMC between 2006 and 2015. RESULTS A total of 22 pediatric (< 14 years of age) patients with ependymoma were included (median age: 4 years, range: 1–9 years). Of these, four (18.2%) were < 3 years. Demographic, pathological and radiological features were not found to be of prognostic significance. Gross total resection (GTR) and subtotal resection (STR) was individually achievable in 9 (42.9%) cases, while near total resection (NTR) was performed in 14.3% of the cases. Median time from surgery to start of radiotherapy (RT) was 62 days. RT dose of 55.8 Gy (both mean and median) with median fractions of 30 days was given to 17 (77.3%) patients. Only 4 (18.18%) of the children received chemotherapy. With all modalities of treatment, median event-free survival (EFS) and overall survival (OS) from the first day of diagnosis were 1.57 years (range, 0.00–6.47) and 1.96 years (range, 0.01–7.37) respectively. At 4-year follow up, the overall EFS was about 34%, and OS was approximately 58%. CONCLUSION This study is the first such kind of study from Kingdom of Saudi Arabia to describe the outcomes of 22 patients with childhood ependymoma and treated with surgical resection followed by chemotherapy or radiotherapy. KEY WORDS Ependymoma, Child, Surgery, Radiotherapy, Chemotherapy, Cancer treatment, Saudi Arabia