Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ

Objective. We aim to explore the effects and mechanisms of Jinlida granules on the dysfunction of hypothalamic-pituitary-thyroid (HPT) axis in diabetic rats induced by streptozotocin. Methods. A total of 48 SD rats were randomized into normal control group (NC, n=6) and diabetic group (n=42). Rats i...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser:	Liu, Zhimin, Zhang, Danfeng, Dai, Xianliang, Wang, Chaoqun, Huang, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asparagaceae Blood Blood sugar Brain China Cytokines Cytokines - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental Diabetes therapy Diabetic retinopathy Drug dosages Drugs, Chinese Herbal - pharmacology Endocrinology Epithelium Ethylenediaminetetraacetic acid Fasting Gene expression Glucose Granular materials Humans Hypothalamic-pituitary-thyroid axis Hypothalamo-Hypophyseal System - drug effects Hypothalamus Hypothyroidism Inflammation Insulin resistance Interleukin 6 Iodides Iodine Laboratory animals Leguminosae Liver Male Medical research Medicine, Experimental Metabolism Metformin Mice NF-κB protein Pituitary Pituitary-Adrenal System - drug effects Random Allocation Rats Rats, Sprague-Dawley Reabsorption RNA Rodents Saxagliptin Sodium Sodium iodide Sodium iodide symporter Streptozocin Thyroid Thyroid diseases Thyroid Gland Thyroid-stimulating hormone receptors Thyroxine Triiodothyronine Tumor necrosis factor-α
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Zusammenfassung:	Objective. We aim to explore the effects and mechanisms of Jinlida granules on the dysfunction of hypothalamic-pituitary-thyroid (HPT) axis in diabetic rats induced by streptozotocin. Methods. A total of 48 SD rats were randomized into normal control group (NC, n=6) and diabetic group (n=42). Rats in diabetic group were randomly divided into diabetes mellitus (DM) control group, low, medium, and high doses of Jinlida group (JL, JM, and JH), medium dose of Jinlida plus Tongxinluo group (JM + T), metformin group (Met), and Saxagliptin group (Sax) (n=6 in each group). Diabetic rats were obtained by intraperitoneal injection of streptozotocin and sacrificed at 8 weeks to examine the function of HPT axis. Results. Levels of fasting blood glucose (P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2018/4764030