miR-30 Family: A Promising Regulator in Development and Disease

miR-30 Family: A Promising Regulator in Development and Disease

MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate posttranscriptional expression of target genes. Accumulating evidences have demonstrated that the miR-30 family, as a member of microRNAs, played a crucial regulating role in the development of tissues and organs and the pathogenes...

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Veröffentlicht in:BioMed research international 2018-01, Vol.2018 (2018), p.1-8
Hauptverfasser: Xu, Lin, Liu, Yun, Guo, Mengmeng, Wang, Hairong, Jia, Li, Hu, Lin, Liu, Shiming, Mao, Ling, Chen, Chao
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Apoptosis
Disease
Gene expression
Growth and Development
Kinases
Medical research
Medicine, Experimental
MicroRNA
MicroRNAs
miRNA
Oncorhynchus mykiss
Organs
Pathogenesis
Post-transcription
Protein binding
Proteins
Reproductive system
Review
Ribonuclease
RNA polymerase
Stem cells
Tissues
Transcription factors
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Zusammenfassung:MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate posttranscriptional expression of target genes. Accumulating evidences have demonstrated that the miR-30 family, as a member of microRNAs, played a crucial regulating role in the development of tissues and organs and the pathogenesis of clinical diseases, which indicated that it may be a promising regulator in development and disease. This review aims to clarify the current progress on the regulating role of miR-30 family in tissues and organs development and related disease and highlight their research prospective in the future.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/9623412