Single-Cell Transcriptomic Analysis of Tumor Heterogeneity

Single-Cell Transcriptomic Analysis of Tumor Heterogeneity

Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. In the future these technologies might...

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Veröffentlicht in:Trends in Cancer 2018-04, Vol.4 (4), p.264-268
Hauptverfasser: Levitin, Hanna Mendes, Yuan, Jinzhou, Sims, Peter A
Format: Artikel
Sprache:eng
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Zusammenfassung:Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. In the future these technologies might inform the selection of targeted combination therapies and enrollment criteria for clinical trials.
ISSN:2405-8033
2405-8025
DOI:10.1016/j.trecan.2018.02.003