Persistence of abnormalities in white matter in children with type 1 diabetes

Aims/hypothesis Prior studies suggest white matter growth is reduced and white matter microstructure is altered in the brains of young children with type 1 diabetes when compared with brains of non-diabetic children, due in part to adverse effects of hyperglycaemia. This longitudinal observational s...

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Veröffentlicht in:	Diabetologia 2018-07, Vol.61 (7), p.1538-1547
Hauptverfasser:	Fox, Larry A., Hershey, Tamara, Mauras, Nelly, Arbeláez, Ana Maria, Tamborlane, William V., Buckingham, Bruce, Tsalikian, Eva, Englert, Kim, Raman, Mira, Jo, Booil, Shen, Hanyang, Reiss, Allan, Mazaika, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Anisotropy Attention deficit hyperactivity disorder Biomarkers - blood Blood Glucose - metabolism Case-Control Studies Child Child Development Child, Preschool Children Cognitive ability Cognitive Dysfunction - etiology Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diffusion Tensor Imaging Female Glucose monitoring Glycated Hemoglobin A - metabolism Human Physiology Humans Hyperglycemia Internal Medicine Leukoencephalopathies - diagnostic imaging Leukoencephalopathies - etiology Leukoencephalopathies - physiopathology Longitudinal Studies Magnetic Resonance Imaging Male Medicine Medicine & Public Health Metabolic Diseases Neurological disorders Pediatrics Prognosis Risk Factors Substantia alba Time Factors United States
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Zusammenfassung:	Aims/hypothesis Prior studies suggest white matter growth is reduced and white matter microstructure is altered in the brains of young children with type 1 diabetes when compared with brains of non-diabetic children, due in part to adverse effects of hyperglycaemia. This longitudinal observational study examines whether dysglycaemia alters the developmental trajectory of white matter microstructure over time in young children with type 1 diabetes. Methods One hundred and eighteen children, aged 4 to
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-018-4610-6