Aquaporin‐4 knockout mice exhibit increased hypnotic susceptibility to ketamine

Purpose This study examines anesthetic/hypnotic effects of ketamine in AQP4 knockout (KO) and wild‐type (WT) mice with the particular focus on neurotransmission. Materials and Methods Ketamine (100 mg/kg) was intraperitoneally injected in 16 WT and 16 KO mice. The hypnotic potencies were evaluated b...

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Veröffentlicht in:	Brain and behavior 2018-06, Vol.8 (6), p.e00990-n/a
Hauptverfasser:	Lv, Yunluo, Dai, Wangshu, Ge, Ai, Fan, Yi, Hu, Gang, Zeng, Yinming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Animals Aquaporin 4 - deficiency aquaporin‐4 Excitatory Amino Acid Antagonists - pharmacology gamma-Aminobutyric Acid Hypnotics and Sedatives - pharmacology Ketamine Ketamine - pharmacology loss of the righting reflex Male Mice, Knockout microdialysis Microdialysis - methods Neurotransmitter Agents - metabolism Original Research Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Reflex, Righting - drug effects Rodents synaptic transmission
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Zusammenfassung:	Purpose This study examines anesthetic/hypnotic effects of ketamine in AQP4 knockout (KO) and wild‐type (WT) mice with the particular focus on neurotransmission. Materials and Methods Ketamine (100 mg/kg) was intraperitoneally injected in 16 WT and 16 KO mice. The hypnotic potencies were evaluated by the loss of the righting reflex (LORR). The amino acids neurotransmitter levels in prefrontal cortex were measured by microdialysis. Results This study demonstrated that AQP4 knockout significantly shortened the latency compared with WT mice (98.0 ± 4.2 vs. 138.1 ± 15.0 s, p
ISSN:	2162-3279 2162-3279
DOI:	10.1002/brb3.990