Hypocrellin B‐loaded, folate‐conjugated polymeric micelle for intraperitoneal targeting of ovarian cancer in vitro and in vivo

Photodynamic therapy (PDT) is considered an innovative and attractive modality to treat ovarian cancer. In the present study, a biodegradable polymer poly (ethylene glycol) (PEG)‐poly (lactic acid)(PLA)‐folate (FA‐PEG‐PLA) was prepared in order to synthesize an active‐targeting, water‐soluble and ph...

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Veröffentlicht in:	Cancer science 2018-06, Vol.109 (6), p.1958-1969
Hauptverfasser:	Li, Jie, Yao, Shu, Wang, Kai, Lu, Zaijun, Su, Xuantao, Li, Li, Yuan, Cunzhong, Feng, Jinbo, Yan, Shi, Kong, Beihua, Song, Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antitumor activity Biocompatibility Biodegradability Cancer therapies Cell Line, Tumor Cytotoxicity Drug Carriers - chemistry Drug delivery Drug delivery systems Drug development Drug dosages Drug Liberation Encapsulation Female folate Folic acid Folic Acid - analogs & derivatives Folic Acid - chemistry Gynecology Humans intraperitoneal Kidneys Laboratories Medical prognosis Mice, Nude Micelles nanoparticle Original Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Perylene - administration & dosage Perylene - analogs & derivatives Perylene - chemistry Perylene - pharmacokinetics Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacokinetics Polyesters - chemistry Polyethylene glycol Polyethylene Glycols - chemistry Polylactic acid Polymers - chemistry Quinones - administration & dosage Quinones - chemistry Quinones - pharmacokinetics Rats, Sprague-Dawley Solvents Tissue Distribution tumor targeting Tumors Vitamin B Xenograft Model Antitumor Assays
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Zusammenfassung:	Photodynamic therapy (PDT) is considered an innovative and attractive modality to treat ovarian cancer. In the present study, a biodegradable polymer poly (ethylene glycol) (PEG)‐poly (lactic acid)(PLA)‐folate (FA‐PEG‐PLA) was prepared in order to synthesize an active‐targeting, water‐soluble and pharmacomodulated photosensitizer nanocarrier. Drug‐loading content, encapsulation efficiency, in vitro and in vivo release were characterized, in which hypocrellin B (HB)/FA‐PEG‐PLA micelles had a high encapsulation efficiency and much slower control release for drugs compared to free drugs (P
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.13605