Less cholesterol means better tumor killing for cytotoxic T9 cells

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2018-06, Vol.215 (6), p.1505-1506
Hauptverfasser:	Griesenauer, Brad, Paczesny, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8 antigen CD8-Positive T-Lymphocytes Cell Differentiation Cholesterol Cytotoxicity Differentiation Humans Interleukin 9 Liver Liver X receptors Lymphocytes Lymphocytes T Neoplasms Receptor mechanisms Receptors SUMO protein Tumors
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Beschreibung
Zusammenfassung:	In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.
ISSN:	0022-1007 1540-9538 1540-9538
DOI:	10.1084/jem.20180852