FoxO transcription factors in cancer metabolism

FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging...

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Veröffentlicht in:	Seminars in cancer biology 2018-06, Vol.50, p.65-76
Hauptverfasser:	Yadav, Raj Kumar, Chauhan, Anoop Singh, Zhuang, Li, Gan, Boyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Cancer metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FoxO Homeostasis Humans Metabolic Networks and Pathways - genetics mTOR Myc Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Tumor suppression
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