FoxO transcription factors in cancer metabolism

FoxO transcription factors in cancer metabolism

FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging...

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Veröffentlicht in:Seminars in cancer biology 2018-06, Vol.50, p.65-76
Hauptverfasser: Yadav, Raj Kumar, Chauhan, Anoop Singh, Zhuang, Li, Gan, Boyi
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis - genetics
Cancer metabolism
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
FoxO
Homeostasis
Humans
Metabolic Networks and Pathways - genetics
mTOR
Myc
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Tumor suppression
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Beschreibung
Zusammenfassung:FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2018.01.004