FoxO transcription factors in cancer metabolism
FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging...
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| Veröffentlicht in: | Seminars in cancer biology 2018-06, Vol.50, p.65-76 |
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| container_title | Seminars in cancer biology |
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| creator | Yadav, Raj Kumar Chauhan, Anoop Singh Zhuang, Li Gan, Boyi |
| description | FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment. |
| doi_str_mv | 10.1016/j.semcancer.2018.01.004 |
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| ispartof | Seminars in cancer biology, 2018-06, Vol.50, p.65-76 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apoptosis - genetics Cancer metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FoxO Homeostasis Humans Metabolic Networks and Pathways - genetics mTOR Myc Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Tumor suppression |
| title | FoxO transcription factors in cancer metabolism |
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