Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010-2015
Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. Data were collected on IAE cases reported through the National Epidemiological Surveillance of In...
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| Veröffentlicht in: | Clinical infectious diseases 2018-06, Vol.66 (12), p.1831-1837 |
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| creator | Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori |
| description | Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited.
Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes.
Among 385 IAE cases, median age at diagnosis was 7 years (range, 0-90), and 283 (74%) were aged |
| doi_str_mv | 10.1093/cid/cix1126 |
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Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes.
Among 385 IAE cases, median age at diagnosis was 7 years (range, 0-90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5-12 years) children (38%), followed by children aged 2-4 years (21%) and adults aged 18-49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18-49 (17%) and 50-64 (19%) years. Case fatality proportion was highest in those aged 40-64 (17%) and ≥65 (20%) years.
We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/cix1126</identifier><identifier>PMID: 29293894</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Adults ; Age Factors ; Aged ; Aged, 80 and over ; and Commentaries ; Brain Diseases - mortality ; Brain Diseases - virology ; Cerebrospinal fluid ; Child ; Child, Preschool ; Children ; Encephalopathy ; Epidemiological Monitoring ; Epidemiology ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infectious diseases ; Influenza ; Influenza A ; Influenza A virus - isolation & purification ; Influenza, Human - complications ; Influenza, Human - epidemiology ; Japan - epidemiology ; Male ; Middle Aged ; Mortality ; Patient Outcome Assessment ; Pleocytosis ; Seizures ; Severity of Illness Index ; Viruses ; Young Adult</subject><ispartof>Clinical infectious diseases, 2018-06, Vol.66 (12), p.1831-1837</ispartof><rights>Copyright Oxford University Press Jun 15, 2018</rights><rights>The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-eb84da6e20fdadb5150f162fdb57faaa75c6b08c26b66c8ba45a400795fc6ea13</citedby><cites>FETCH-LOGICAL-c559t-eb84da6e20fdadb5150f162fdb57faaa75c6b08c26b66c8ba45a400795fc6ea13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29293894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okuno, Hideo</creatorcontrib><creatorcontrib>Yahata, Yuichiro</creatorcontrib><creatorcontrib>Tanaka-Taya, Keiko</creatorcontrib><creatorcontrib>Arai, Satoru</creatorcontrib><creatorcontrib>Satoh, Hiroshi</creatorcontrib><creatorcontrib>Morino, Saeko</creatorcontrib><creatorcontrib>Shimada, Tomoe</creatorcontrib><creatorcontrib>Sunagawa, Tomimasa</creatorcontrib><creatorcontrib>Uyeki, Timothy M</creatorcontrib><creatorcontrib>Oishi, Kazunori</creatorcontrib><title>Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010-2015</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited.
Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes.
Among 385 IAE cases, median age at diagnosis was 7 years (range, 0-90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5-12 years) children (38%), followed by children aged 2-4 years (21%) and adults aged 18-49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18-49 (17%) and 50-64 (19%) years. Case fatality proportion was highest in those aged 40-64 (17%) and ≥65 (20%) years.
We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>and Commentaries</subject><subject>Brain Diseases - mortality</subject><subject>Brain Diseases - virology</subject><subject>Cerebrospinal fluid</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Encephalopathy</subject><subject>Epidemiological Monitoring</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A virus - isolation & purification</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - epidemiology</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patient Outcome Assessment</subject><subject>Pleocytosis</subject><subject>Seizures</subject><subject>Severity of Illness Index</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1r1jAUxoM43JxeeS8BbwZaTdImTW4GL2XqxmA3eh1O03TNaJOapLr515u516FenA84Px6ew4PQK0reU6LqD8YNpW4pZeIJOqK8bivBFX1adsJl1chaHqLnKd0QQqkk_Bk6ZIqpWqrmCP3oJohgso0uZWcSBj_gqy2bsNiEw4jP_Thv1v-EapdSMA6yHfCZN3adYA4r5OkOd5AKvFuCv8bd5OYhWv9baDdsc07YeXwBK_h3mBFKqtL4C3Qwwpzsy_08Rl8_nn3pPleXV5_Ou91lZThXubK9bAYQlpFxgKHnlJORCjaWtR0BoOVG9EQaJnohjOyh4dAQ0io-GmGB1sfo9EF33frFDsb6HGHWa3QLxDsdwOl_L95N-jp811xJJmldBE72AjF822zKenHJ2HkGb8OWNFWyYaLmLSvom__Qm7BFX97TjMgCUcrvHb19oEwMKUU7PpqhRN8Hqkugeh9ooV__7f-R_ZNg_QvrI53E</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Okuno, Hideo</creator><creator>Yahata, Yuichiro</creator><creator>Tanaka-Taya, Keiko</creator><creator>Arai, Satoru</creator><creator>Satoh, Hiroshi</creator><creator>Morino, Saeko</creator><creator>Shimada, Tomoe</creator><creator>Sunagawa, Tomimasa</creator><creator>Uyeki, Timothy M</creator><creator>Oishi, Kazunori</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010-2015</title><author>Okuno, Hideo ; Yahata, Yuichiro ; Tanaka-Taya, Keiko ; Arai, Satoru ; Satoh, Hiroshi ; Morino, Saeko ; Shimada, Tomoe ; Sunagawa, Tomimasa ; Uyeki, Timothy M ; Oishi, Kazunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-eb84da6e20fdadb5150f162fdb57faaa75c6b08c26b66c8ba45a400795fc6ea13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>and Commentaries</topic><topic>Brain Diseases - mortality</topic><topic>Brain Diseases - virology</topic><topic>Cerebrospinal fluid</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Encephalopathy</topic><topic>Epidemiological Monitoring</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Influenza A</topic><topic>Influenza A virus - isolation & purification</topic><topic>Influenza, Human - complications</topic><topic>Influenza, Human - epidemiology</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patient Outcome Assessment</topic><topic>Pleocytosis</topic><topic>Seizures</topic><topic>Severity of Illness Index</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okuno, Hideo</creatorcontrib><creatorcontrib>Yahata, Yuichiro</creatorcontrib><creatorcontrib>Tanaka-Taya, Keiko</creatorcontrib><creatorcontrib>Arai, Satoru</creatorcontrib><creatorcontrib>Satoh, Hiroshi</creatorcontrib><creatorcontrib>Morino, Saeko</creatorcontrib><creatorcontrib>Shimada, Tomoe</creatorcontrib><creatorcontrib>Sunagawa, Tomimasa</creatorcontrib><creatorcontrib>Uyeki, Timothy M</creatorcontrib><creatorcontrib>Oishi, Kazunori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okuno, Hideo</au><au>Yahata, Yuichiro</au><au>Tanaka-Taya, Keiko</au><au>Arai, Satoru</au><au>Satoh, Hiroshi</au><au>Morino, Saeko</au><au>Shimada, Tomoe</au><au>Sunagawa, Tomimasa</au><au>Uyeki, Timothy M</au><au>Oishi, Kazunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010-2015</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>66</volume><issue>12</issue><spage>1831</spage><epage>1837</epage><pages>1831-1837</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited.
Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes.
Among 385 IAE cases, median age at diagnosis was 7 years (range, 0-90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5-12 years) children (38%), followed by children aged 2-4 years (21%) and adults aged 18-49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18-49 (17%) and 50-64 (19%) years. Case fatality proportion was highest in those aged 40-64 (17%) and ≥65 (20%) years.
We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29293894</pmid><doi>10.1093/cid/cix1126</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Adults Age Factors Aged Aged, 80 and over and Commentaries Brain Diseases - mortality Brain Diseases - virology Cerebrospinal fluid Child Child, Preschool Children Encephalopathy Epidemiological Monitoring Epidemiology Female Humans Incidence Infant Infant, Newborn Infectious diseases Influenza Influenza A Influenza A virus - isolation & purification Influenza, Human - complications Influenza, Human - epidemiology Japan - epidemiology Male Middle Aged Mortality Patient Outcome Assessment Pleocytosis Seizures Severity of Illness Index Viruses Young Adult |
| title | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010-2015 |
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