Mobile DNA in Health and Disease

Mobile DNA in Health and Disease

More than half the human genome is derived from transposable elements (also known as mobile DNA or “jumping genes”); some of these elements have been repurposed over time in the service of evolution. “Live” mobile elements are a rare cause of genetic disease.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2017-07, Vol.377 (4), p.361-370
Hauptverfasser: Kazazian, Haig H, Moran, John V
Format: Artikel
Sprache:eng
Schlagworte:
Chromosomes
Deoxyribonucleic acid
Disease
Disease - genetics
DNA
DNA Transposable Elements
Enzymes
Female
Gene expression
Genome, Human
Genomes
Genomic Instability
Hemophilia A - genetics
Humans
Long Interspersed Nucleotide Elements - physiology
Male
Mutagens - metabolism
Proteins
Retroelements - physiology
RNA - metabolism
Transcription, Genetic
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Beschreibung
Zusammenfassung:More than half the human genome is derived from transposable elements (also known as mobile DNA or “jumping genes”); some of these elements have been repurposed over time in the service of evolution. “Live” mobile elements are a rare cause of genetic disease.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra1510092