Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications

Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications

Background Basal cell carcinoma (BCC) has a characteristic stroma, but less is known about the dermal characteristics associated with melanoma in situ (MIS) and actinic keratosis (AK). Materials and methods Dermal changes were studied in 301 specimens of AK, BCC and MIS. Subsequently, blinded images...

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Veröffentlicht in:Journal of cutaneous pathology 2013-12, Vol.40 (12), p.1014-1020
Hauptverfasser: Kazlouskaya, Viktoryia, Malhotra, Saurabh, Navarro, Raquel, Wu, Karen Nguyen, Shvartsbeyn, Marianna, Shengli, Chen, Gui, Jiang, Elston, Dirk M.
Format: Artikel
Sprache:eng
Schlagworte:
cancer
Carcinoma, Basal Cell - pathology
Dermis - pathology
Female
Humans
Keratosis, Actinic - pathology
Male
malignant melanoma
Melanoma - pathology
non-melanoma skin cancer
pathology
pathology dermatopathology
Retrospective Studies
Skin Neoplasms - pathology
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Zusammenfassung:Background Basal cell carcinoma (BCC) has a characteristic stroma, but less is known about the dermal characteristics associated with melanoma in situ (MIS) and actinic keratosis (AK). Materials and methods Dermal changes were studied in 301 specimens of AK, BCC and MIS. Subsequently, blinded images of dermal changes from 90 randomly selected cases of those entities were used to assess the predictive value of the dermal changes. Agreement with the final diagnosis was calculated using kappa coefficient (κ). Results Fibromyxoid stroma was present in 82% of BCC cases; fibrous stroma was seen in 25% of BCC, 58% of MIS and 35.6% of AK specimens (p 
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.12235