Failure of Azithromycin 2.0 g in the Treatment of Gonococcal Urethritis Caused by High-Level Resistance in California

We report a treatment failure to azithromycin 2.0 g caused by a urethral Neisseria gonorrhoeae isolate with high-level azithromycin resistance in California. This report describes the epidemiological case investigation and phenotypic and genetic characterization of the treatment failure isolate.

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Bibliographische Detailangaben
Veröffentlicht in:	Sexually transmitted diseases 2015-05, Vol.42 (5), p.279-280
Hauptverfasser:	Gose, Severin O., Soge, Olusegun O., Beebe, James L., Nguyen, Duylinh, Stoltey, Juliet E., Bauer, Heidi M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - administration & dosage Antibiotics Azithromycin - pharmacology California - epidemiology Ceftriaxone - administration & dosage Contact Tracing Drug resistance Drug Resistance, Bacterial Epidemiology Female Genetics Genotype & phenotype Gonorrhea Gonorrhea - drug therapy Gonorrhea - genetics Gonorrhea - microbiology Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Population Surveillance Treatment Failure United States - epidemiology Urethritis - drug therapy Urethritis - etiology Urethritis - genetics
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Beschreibung
Zusammenfassung:	We report a treatment failure to azithromycin 2.0 g caused by a urethral Neisseria gonorrhoeae isolate with high-level azithromycin resistance in California. This report describes the epidemiological case investigation and phenotypic and genetic characterization of the treatment failure isolate.
ISSN:	0148-5717 1537-4521
DOI:	10.1097/OLQ.0000000000000265