Mucosal microbiome dysbiosis in gastric carcinogenesis

ObjectivesWe aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.DesignWe performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gast...

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Veröffentlicht in:	Gut 2018-06, Vol.67 (6), p.1024-1032
Hauptverfasser:	Coker, Olabisi Oluwabukola, Dai, Zhenwei, Nie, Yongzhan, Zhao, Guijun, Cao, Lei, Nakatsu, Geicho, Wu, William KK, Wong, Sunny Hei, Chen, Zigui, Sung, Joseph J Y, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Area Under Curve Carcinogenesis - pathology Cell Transformation, Neoplastic - pathology China Dysbiosis - microbiology Female Gastric Mucosa - microbiology Gastric Mucosa - pathology Humans Male Microbiota - genetics Middle Aged RNA, Ribosomal, 16S Stomach Stomach - microbiology Stomach - pathology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Young Adult
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Zusammenfassung:	ObjectivesWe aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.DesignWe performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi’an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China.ResultsWe observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q
ISSN:	0017-5749 1468-3288
DOI:	10.1136/gutjnl-2017-314281