IV fosphenytoin in obese patients: Dosing strategies, safety, and efficacy

IV fosphenytoin in obese patients: Dosing strategies, safety, and efficacy

Previous studies evaluated the disposition of IV phenytoin loading doses and found that obese patients had increased drug distribution into excess body weight, larger volumes of distribution, and longer half-lives when compared to their nonobese counterparts. We assess the safety and efficacy of fos...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurology. Clinical practice 2017-02, Vol.7 (1), p.45-52
Hauptverfasser: Clark, Sarah L, Leloux, Megan R, Dierkhising, Ross A, Cascino, Gregory D, Hocker, Sara E
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Previous studies evaluated the disposition of IV phenytoin loading doses and found that obese patients had increased drug distribution into excess body weight, larger volumes of distribution, and longer half-lives when compared to their nonobese counterparts. We assess the safety and efficacy of fosphenytoin loading doses in patients with different body mass indices (BMIs). A retrospective chart review was conducted in 410 patients who received fosphenytoin. Patients were divided into 2 groups: BMI
ISSN:2163-0402
2163-0933
DOI:10.1212/CPJ.0000000000000322