Urine Tuberculosis Lipoarabinomannan Predicts Mortality in Hospitalized Human Immunodeficiency Virus-Infected Children

Urine Tuberculosis Lipoarabinomannan Predicts Mortality in Hospitalized Human Immunodeficiency Virus-Infected Children

Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in human immunodeficiency virus (HIV)–infected adults with tuberculosis. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among those with positive LAM (127...

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Veröffentlicht in:Clinical infectious diseases 2018-05, Vol.66 (11), p.1798-1801
Hauptverfasser: LaCourse, Sylvia M, Cranmer, Lisa M, Njuguna, Irene N, Gatimu, John, Stern, Joshua, Maleche-Obimbo, Elizabeth, Walson, Judd L, Wamalwa, Dalton, John-Stewart, Grace C, Pavlinac, Patricia B
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Antiretroviral drugs
Brief Reports
Child
Child, Preschool
Children
Confidence intervals
Diagnostic systems
Health risks
HIV
HIV Infections - complications
HIV Infections - mortality
Hospitalization
Human immunodeficiency virus
Humans
Infant
Lipopolysaccharides - urine
Mortality
Mycobacterium tuberculosis
Risk Factors
Tuberculosis
Tuberculosis - microbiology
Tuberculosis - urine
Urine
Viruses
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Zusammenfassung:Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in human immunodeficiency virus (HIV)–infected adults with tuberculosis. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among those with positive LAM (127 vs 31 per 100 person-years; adjusted hazard ratio, 4.92; 95% confidence interval [CI], 1.79–13.49; P = .002). Lipoarabinomannan identifies HIV-infected children at risk for death potentially missed by respiratory sampling.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciy011