IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects

Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like gr...

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Veröffentlicht in:	Medicine (Baltimore) 2018-05, Vol.97 (19), p.e0702-e0702
Hauptverfasser:	Al-Daghri, Nasser M., Yakout, Sobhy M., Wani, Kaiser, Khattak, Malak Nawaz Khan, Garbis, Spiro D., Chrousos, George P., Al-Attas, Omar S., Alokail, Majed S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - blood Cholecalciferol - administration & dosage Dietary Supplements Female Humans Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor I - metabolism Male Observational Study Overweight - blood Overweight - complications Prospective Studies Saudi Arabia Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy
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Zusammenfassung:	Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000010702