High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial

BACKGROUND:Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous “more versus less statins” trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS:In this prospe...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2018-05, Vol.137 (19), p.1997-2009
Hauptverfasser:	Taguchi, Isao, Iimuro, Satoshi, Iwata, Hiroshi, Takashima, Hiroaki, Abe, Mitsuru, Amiya, Eisuke, Ogawa, Takanori, Ozaki, Yukio, Sakuma, Ichiro, Nakagawa, Yoshihisa, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Hokimoto, Seiji, Miyauchi, Katsumi, Yamazaki, Tsutomu, Ito, Hiroshi, Otsuji, Yutaka, Kimura, Kazuo, Takahashi, Jun, Hirayama, Atsushi, Yokoi, Hiroyoshi, Kitagawa, Kazuo, Urabe, Takao, Okada, Yasushi, Terayama, Yasuo, Toyoda, Kazunori, Nagao, Takehiko, Matsumoto, Masayasu, Ohashi, Yasuo, Kaneko, Tetsuji, Fujita, Retsu, Ohtsu, Hiroshi, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Inoue, Teruo, Matsuzaki, Masunori, Nagai, Ryozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood C-Reactive Protein - metabolism Cholesterol, LDL - blood Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary Artery Disease - mortality Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Dyslipidemias - mortality Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Inflammation Mediators - blood Japan - epidemiology Male Middle Aged Original s Prospective Studies Quinolines - administration & dosage Quinolines - adverse effects Risk Assessment Risk Factors Time Factors Treatment Outcome
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Zusammenfassung:	BACKGROUND:Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous “more versus less statins” trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS:In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C)
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.117.032615