Tetraspanin blockage reduces exosome-mediated HIV-1 entry

HIV-1 is one of the most studied retroviruses. The role of exosomes in HIV-1 entry and pathogenesis are beginning to be appreciated. Exosomes can incorporate host proteins that are also contained in viruses (e.g., tetraspanins).

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Bibliographische Detailangaben
Veröffentlicht in:	Archives of virology 2018-06, Vol.163 (6), p.1683-1689
Hauptverfasser:	Sims, Brian, Farrow, Anitra L., Williams, Sparkle D., Bansal, Anju, Krendelchtchikov, Alexandre, Matthews, Qiana L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - pharmacology Biomedical and Life Sciences Biomedicine CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell Line Culture Media, Conditioned - chemistry Exosomes Exosomes - chemistry Gene Expression HEK293 Cells HIV-1 - drug effects HIV-1 - physiology Humans Infectious Diseases Medical Microbiology Milk, Human - chemistry Monocytes - drug effects Monocytes - immunology Monocytes - virology Rapid Communication Tetraspanin 28 - antagonists & inhibitors Tetraspanin 28 - genetics Tetraspanin 28 - immunology Tetraspanin 29 - antagonists & inhibitors Tetraspanin 29 - genetics Tetraspanin 29 - immunology Virology Virus Internalization - drug effects
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Beschreibung
Zusammenfassung:	HIV-1 is one of the most studied retroviruses. The role of exosomes in HIV-1 entry and pathogenesis are beginning to be appreciated. Exosomes can incorporate host proteins that are also contained in viruses (e.g., tetraspanins).
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-018-3737-6