Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma

Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma

Clustered miRNAs can affect functioning of downstream pathways due to possible coordinated function. We observed 78–88% of the miR-379/miR-656 cluster (C14MC) miRNAs were downregulated in three sub-types of diffuse gliomas, which was also corroborated with analysis from The Cancer Genome Atlas (TCGA...

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Veröffentlicht in:Scientific reports 2018-05, Vol.8 (1), p.7673-10, Article 7673
Hauptverfasser: Nayak, Subhashree, Aich, Meghali, Kumar, Anupam, Sengupta, Suman, Bajad, Prajakta, Dhapola, Parashar, Paul, Deepanjan, Narta, Kiran, Purkrait, Suvendu, Mehani, Bharati, Suri, Ashish, Chakraborty, Debojyoti, Mukhopadhyay, Arijit, Sarkar, Chitra
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Sprache:eng
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Apoptosis
Brain cancer
Cell proliferation
CRISPR
Data processing
Genomes
Glioblastoma
Glioblastoma cells
Glioma
Humanities and Social Sciences
miRNA
multidisciplinary
Phenotypes
Science
Science (multidisciplinary)
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Zusammenfassung:Clustered miRNAs can affect functioning of downstream pathways due to possible coordinated function. We observed 78–88% of the miR-379/miR-656 cluster (C14MC) miRNAs were downregulated in three sub-types of diffuse gliomas, which was also corroborated with analysis from The Cancer Genome Atlas (TCGA) datasets. The miRNA expression levels decreased with increasing tumor grade, indicating this downregulation as an early event in gliomagenesis. Higher expression of the C14MC miRNAs significantly improved glioblastioma prognosis (Pearson’s r = 0.62; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-26000-8