Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank

AbstractObjectiveTo determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.DesignMendelian randomisation study.SettingUK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.ParticipantsEuropean descent pa...

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Veröffentlicht in:	BMJ (Online) 2018-05, Vol.361, p.k1767-k1767
Hauptverfasser:	Carreras-Torres, Robert, Johansson, Mattias, Haycock, Philip C, Relton, Caroline L, Davey Smith, George, Brennan, Paul, Martin, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Biological Specimen Banks Body fat Body Mass Index Body measurements Cigarettes Female Health behavior Humans Male Mendelian Randomization Analysis Middle Aged Obesity Obesity - epidemiology Obesity - genetics Obesity - psychology Odds Ratio Prevalence Public health Risk Factors Smoking Smoking - genetics Smoking - psychology Standard deviation United Kingdom Waist Circumference
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Beschreibung
Zusammenfassung:	AbstractObjectiveTo determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.DesignMendelian randomisation study.SettingUK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.ParticipantsEuropean descent participants from the UK Biobank cohort (n=372 791) and the TAG consortium (n=74 035).Main outcome measuresRisk of current and past smoking, number of cigarettes smoked per day, age of smoking initiation.ResultsThe Mendelian randomisation analysis indicated that each standard deviation increment in body mass index (4.6) increased the risk of being a smoker (odds ratio 1.18 (95% confidence interval 1.13 to 1.23), P
ISSN:	0959-8138 1756-1833
DOI:	10.1136/bmj.k1767