Trisomy 13‐confined placental mosaicism: is there an increased risk of gestational hypertensive disorders?

What's already known about this topic? Trisomy 13 (T13) pregnancies are associated with increased risk of gestational hypertensive disorders (GHDs). It is unclear if false positive cell‐free DNA results for T13, which may be caused by confined placental mosaicism, are associated with increased...

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Veröffentlicht in:	Prenatal diagnosis 2017-09, Vol.37 (9), p.938-939
Hauptverfasser:	Dotters‐Katz, Sarah K., Hardisty, Emily, Campbell, Erin, Vora, Neeta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cell-Free Nucleic Acids - blood Deoxyribonucleic acid Disorders DNA False Positive Reactions Female Humans Hypertension Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - etiology Hypertension, Pregnancy-Induced - genetics Infant, Newborn Mosaicism Patau's syndrome Placenta Placenta - metabolism Placenta - pathology Pregnancy Prenatal Diagnosis - methods Risk Risk Factors Trisomy Trisomy 13 Syndrome - diagnosis Trisomy 13 Syndrome - genetics Trisomy 13 Syndrome - metabolism
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Zusammenfassung:	What's already known about this topic? Trisomy 13 (T13) pregnancies are associated with increased risk of gestational hypertensive disorders (GHDs). It is unclear if false positive cell‐free DNA results for T13, which may be caused by confined placental mosaicism, are associated with increased risk for GHD. What does this study add? Among six women with false positive cell‐free DNA for T13, four developed GHD, raising the possibility that there may be an increased risk for GHD in women with false positive cell‐free DNA results for T13. © 2017 John Wiley & Sons, Ltd.
ISSN:	0197-3851 1097-0223
DOI:	10.1002/pd.5105