Antitumor Effect of the Idiotypic Cascade Induced by an Antibody Encapsulated in Poly(d, l‐lactide‐co‐glycolide) Microspheres

A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly(d, l‐lactide‐co‐glycolide) microspheres with monophosphoryl lipid A. The antitumor effect...

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Veröffentlicht in:	Cancer science 2001-10, Vol.92 (10), p.1110-1115
Hauptverfasser:	Ma, Jie, Luo, Dong, Qi, Weimin, Cao, Liren
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Anti-Idiotypic - biosynthesis Antibodies, Anti-Idiotypic - immunology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Neoplasm - administration & dosage Antibodies, Neoplasm - biosynthesis Antibodies, Neoplasm - immunology Antibody Specificity Antigens Antineoplastic agents Antineoplastic Agents - immunology Antitumor activity Anti‐idiotype Biological and medical sciences Breast cancer Breast Neoplasms - immunology Breast Neoplasms - therapy Drug Carriers Enzyme-Linked Immunosorbent Assay Female Humans Immunogenicity Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Immunoglobulin Idiotypes - administration & dosage Immunoglobulin Idiotypes - immunology Immunoglobulin Idiotypes - metabolism Immunoglobulin Isotypes - biosynthesis Immunoglobulin Isotypes - immunology Immunoglobulin M - biosynthesis Immunoglobulin M - immunology Immunotherapy Immunotherapy - methods Lactic Acid Lipid A Medical sciences Mice Microsphere Microspheres Monoclonal antibodies Monophosphoryl lipid A Neoplasm Transplantation Pharmacology. Drug treatments Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Polymers Statistical analysis Therapeutic applications Time Factors
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Beschreibung
Zusammenfassung:	A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly(d, l‐lactide‐co‐glycolide) microspheres with monophosphoryl lipid A. The antitumor effect of this formulation was investigated in a murine model. The induced Ab2 biologically mimics antigen as it competed with CA15.3 for the same idiotope on Abl. Ab3 induction was also observed. After five sequential administrations of encapsulated antibody, mice showed statistically significant tumor regression. These results indicate that this formulation may serve as a potential treatment for breast cancer.
ISSN:	0910-5050 1347-9032 1349-7006 1876-4673
DOI:	10.1111/j.1349-7006.2001.tb01066.x