Mutation of the SRC Gene in Endometrial Carcinoma
Recently, an activating mutation of the SRC Gene has been implicated in about one‐tenth of advanced colon cancers. The SRC 531 mutation results in truncation of SRC directly C‐terminal to the regulatory Tyr 530 and appears to activate the Tyr 530. To investigate whether mutation of SRC plays an impo...
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Veröffentlicht in: | Cancer science 2000-04, Vol.91 (4), p.395-398 |
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Sprache: | eng |
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Zusammenfassung: | Recently, an activating mutation of the SRC Gene has been implicated in about one‐tenth of advanced colon cancers. The SRC 531 mutation results in truncation of SRC directly C‐terminal to the regulatory Tyr 530 and appears to activate the Tyr 530. To investigate whether mutation of SRC plays an important role in the development and progression of gynecological tumors, we performed mutational analysis of the entire coding region of SRC in 70 ovarian carcinomas, 68 endometrial carcinomas and 3 endometrial stromal sarcomas by means of polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) followed by nucleotide sequencing and restriction fragment length polymorphism (RFLP) analysis. We found one truncated mutation at codon 531 (Gln to Stop) in an endometrial carcinoma. However, we found no mutation of this gene in ovarian carcinoma or endometrial stromal sarcoma. Our results suggest that mutation of SRC may be implicated in a small proportion of endometrial carcinomas. |
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ISSN: | 0910-5050 1347-9032 1349-7006 1876-4673 |
DOI: | 10.1111/j.1349-7006.2000.tb00958.x |