The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease reveal...
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| Veröffentlicht in: | Cancer science 1994-08, Vol.85 (8), p.771-774 |
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| container_title | Cancer science |
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| creator | Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. |
| description | LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver. |
| doi_str_mv | 10.1111/j.1349-7006.1994.tb02946.x |
| format | Article |
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Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1994.tb02946.x</identifier><identifier>PMID: 7928621</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenosine triphosphatase ; Copper ; Hepatitis ; hts ; LEC rat ; Leg ; Linkage analysis ; Liver cancer ; Rapid Communication ; Recombination ; Wilson's disease ; Wilson's disease gene</subject><ispartof>Cancer science, 1994-08, Vol.85 (8), p.771-774</ispartof><rights>Copyright John Wiley & Sons, Inc. 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Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.</description><subject>Adenosine triphosphatase</subject><subject>Copper</subject><subject>Hepatitis</subject><subject>hts</subject><subject>LEC rat</subject><subject>Leg</subject><subject>Linkage analysis</subject><subject>Liver cancer</subject><subject>Rapid Communication</subject><subject>Recombination</subject><subject>Wilson's disease</subject><subject>Wilson's disease gene</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqVkFFLwzAUhYMoc07_Q9AHn1qTNG0WHwTp5iYUBJnsMSRt6lK3ZjaZbv_elo2Jj96X-3DOPffwAXCNUYjbuatCHFEeMISSEHNOQ68Q4TQJtyegf5ROQR9xjIIYxegcXDhXIYQZSkgP9Bgnw4TgPkhnCw3nIzjRtYalbeDcLJ2tbx0cGael0zAz9YeD3kLfOqd6Lb3xxkFbwmw8ga_Su0twVsql01eHPQBvT-NZOg2yl8lz-pgFOY0IDjDhRZ4wGrcdFNFlUSpGSpUPFSkSxXJGKCcJIxIPOVUYRwXNpdQslooopmk0AA_73PVGrXSR69o3cinWjVnJZiesNOKvUpuFeLdfIuaYxwy3ATeHgMZ-brTzorKbpm47C0IRQoTEcee637vyxjrX6PL4ASPR8ReV6CCLDrLo-IsDf7H97fhtlnr3j0uRPo5Z2_EH2eGKcg</recordid><startdate>199408</startdate><enddate>199408</enddate><creator>Ono, Takao</creator><creator>Takada, Shigeyuki</creator><creator>Yoshida, Michihiro C.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>199408</creationdate><title>The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats</title><author>Ono, Takao ; Takada, Shigeyuki ; Yoshida, Michihiro C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4321-129dc6745706b2efdfb72fbc8b2d6b7c72492672a1894b113d4caae75ab2b7e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenosine triphosphatase</topic><topic>Copper</topic><topic>Hepatitis</topic><topic>hts</topic><topic>LEC rat</topic><topic>Leg</topic><topic>Linkage analysis</topic><topic>Liver cancer</topic><topic>Rapid Communication</topic><topic>Recombination</topic><topic>Wilson's disease</topic><topic>Wilson's disease gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ono, Takao</creatorcontrib><creatorcontrib>Takada, Shigeyuki</creatorcontrib><creatorcontrib>Yoshida, Michihiro C.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ono, Takao</au><au>Takada, Shigeyuki</au><au>Yoshida, Michihiro C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats</atitle><jtitle>Cancer science</jtitle><date>1994-08</date><risdate>1994</risdate><volume>85</volume><issue>8</issue><spage>771</spage><epage>774</epage><pages>771-774</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><abstract>LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7928621</pmid><doi>10.1111/j.1349-7006.1994.tb02946.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-5050 |
| ispartof | Cancer science, 1994-08, Vol.85 (8), p.771-774 |
| issn | 0910-5050 1347-9032 1349-7006 1876-4673 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919571 |
| source | IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adenosine triphosphatase Copper Hepatitis hts LEC rat Leg Linkage analysis Liver cancer Rapid Communication Recombination Wilson's disease Wilson's disease gene |
| title | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
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