The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats

LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease reveal...

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Veröffentlicht in:	Cancer science 1994-08, Vol.85 (8), p.771-774
Hauptverfasser:	Ono, Takao, Takada, Shigeyuki, Yoshida, Michihiro C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Copper Hepatitis hts LEC rat Leg Linkage analysis Liver cancer Rapid Communication Recombination Wilson's disease Wilson's disease gene
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Beschreibung
Zusammenfassung:	LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.
ISSN:	0910-5050 1347-9032 1349-7006 1876-4673
DOI:	10.1111/j.1349-7006.1994.tb02946.x