Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate

8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant incr...

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Veröffentlicht in:	Cancer science 1990-03, Vol.81 (3), p.213-215
Hauptverfasser:	Takagi, Atsuya, Sai, Kimie, Umemura, Takashi, Hasegawa, Ryuichi, Kurokawa, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	8‐Hydroxydeoxyguanosine Adipates - administration & dosage Adipates - pharmacology Animals Carcinogenesis Carcinogens - pharmacology Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Deoxyribonucleic acid Di(2‐ethylhexyl)adipate Di(2‐ethylhexyl)phthalate Diethylhexyl Phthalate - administration & dosage Diethylhexyl Phthalate - pharmacology DNA DNA - metabolism DNA Damage Kidneys Liver Liver - drug effects Liver - metabolism Liver Neoplasms, Experimental - chemically induced Male Microbodies - drug effects Microbodies - ultrastructure Peroxisome proliferator Phthalic Acids - pharmacology Rapid Communication Rats Rats, Inbred F344
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Zusammenfassung:	8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8‐OH‐dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.
ISSN:	0910-5050 1347-9032 1349-7006 1876-4673
DOI:	10.1111/j.1349-7006.1990.tb02551.x