Microsatellite genotyping of clinical Candida parapsilosis isolates

is a predominant species found in nosocomial infection, particularly in hospitalized patients. The molecular epidemiology of the clinical strains of this species has not been well studied. The present study was performed with the aim of investigating the microsatellite genotyping of among the Iranian clinical isolates. This study was conducted on 81 independent clinical isolates that were genotyped by using a panel of six microsatellite markers. The short tandem repeat (STR) typing of clinical isolates demonstrated 68 separate genotypes, among which 57 genotypes were observed once and the remaining 11 cases were identified for multiple times. The Simpson's diversity index for the panel of combined six markers yielded a diversity index of 0.9951. The heterogeneity was observed among the Iranian and the Netherlands clinical isolates. As the findings indicated, the clinical isolates from Iran showed a high genetic diversity. It can be concluded that molecular epidemiology could be useful for screening during outbreak investigation where is involved.