Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality

Few studies have investigated the changes in weight that may occur over time among adults with the progression of chronic kidney disease (CKD). Whether such weight changes are independently associated with death after the onset of end-stage renal disease has also not been rigorously examined. Prospective cohort study. We studied 3,933 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a longitudinal cohort of patients with CKD. We also performed similar analyses among 1,067 participants of the African American Study of Kidney Disease and Hypertension (AASK). Estimated glomerular filtration rate (eGFR) and weight change during CKD. Weight and all-cause mortality after dialysis therapy initiation. During a median follow-up of 5.7 years in CRIC, weight change was not linear. Weight was stable until cystatin C–based eGFR (eGFRcys) decreased to 5% annualized weight loss after eGFR decreased to