Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery
An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC ) was 28.3 mg/liter · h. The AUC /MIC rati...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2018-04, Vol.62 (4) |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Grégoire, Matthieu Libois, Julia Brochard Waast, Denis Gaborit, Benjamin Dauty, Marc Deslandes, Guillaume Dailly, Eric Touchais, Sophie Boutoille, David Grégoire, Nicolas Couet, William |
| description | An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC
) was 28.3 mg/liter · h. The AUC
/MIC ratio for unbound concentrations and for sensitive
and
strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery. |
| doi_str_mv | 10.1128/AAC.02432-17 |
| format | Article |
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) was 28.3 mg/liter · h. The AUC
/MIC ratio for unbound concentrations and for sensitive
and
strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.02432-17</identifier><identifier>PMID: 29378714</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Bariatric Surgery ; Life Sciences ; Obesity ; Oxazolidinones ; Pharmaceutical sciences ; Pharmacology ; Tetrazoles</subject><ispartof>Antimicrobial agents and chemotherapy, 2018-04, Vol.62 (4)</ispartof><rights>Copyright © 2018 American Society for Microbiology.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2018 American Society for Microbiology. 2018 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a478t-db36c310068aafec4949cc76b36168eccfc6c0a723462a3a17074da7ab84b64b3</citedby><cites>FETCH-LOGICAL-a478t-db36c310068aafec4949cc76b36168eccfc6c0a723462a3a17074da7ab84b64b3</cites><orcidid>0000-0003-1232-5761 ; 0000-0002-6076-9722 ; 0000-0001-9726-3082 ; 0000-0002-5400-335X ; 0000-0001-6436-3757 ; 0000-0002-7116-8965</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913932/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913932/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29378714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02481229$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Grégoire, Matthieu</creatorcontrib><creatorcontrib>Libois, Julia Brochard</creatorcontrib><creatorcontrib>Waast, Denis</creatorcontrib><creatorcontrib>Gaborit, Benjamin</creatorcontrib><creatorcontrib>Dauty, Marc</creatorcontrib><creatorcontrib>Deslandes, Guillaume</creatorcontrib><creatorcontrib>Dailly, Eric</creatorcontrib><creatorcontrib>Touchais, Sophie</creatorcontrib><creatorcontrib>Boutoille, David</creatorcontrib><creatorcontrib>Grégoire, Nicolas</creatorcontrib><creatorcontrib>Couet, William</creatorcontrib><title>Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC
) was 28.3 mg/liter · h. The AUC
/MIC ratio for unbound concentrations and for sensitive
and
strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.</description><subject>Bariatric Surgery</subject><subject>Life Sciences</subject><subject>Obesity</subject><subject>Oxazolidinones</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology</subject><subject>Tetrazoles</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kclLAzEUh4MoWpebZ8lVcDRbs1yEWlwKBQvWc3iTydhoOyOZaaH-9aZW6wKeQl5-7-O9LwgdU3JOKdMXvV7_nDDBWUbVFupQYnQmu0Zuow4hUmZCE7GH9pvmmaR715BdtMcMV1pR0UGD0QTiDFz9EirfBtfgusRjX4S3ehoKHCoMFb7PfePxCNrgqxZD2fqIryAGaGNw-GEen3xcHqKdEqaNP_o8D9DjzfW4f5cN728H_d4wA6F0mxU5l47TNIoGKL0TRhjnlExlKrV3rnTSEVCMC8mAA1VEiQIU5FrkUuT8AF2uua_zfOYLl0aKMLWvMcwgLm0Nwf5-qcLEPtUL2zWUG84S4HQNmPxpu-sN7aqWbGrKmFnQlD1bZ12smyb6ctNAiV3pt0m__dBvqfpGQzNj9rmexyqp-C978nOPDfjrb_g75OWM-g</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Grégoire, Matthieu</creator><creator>Libois, Julia Brochard</creator><creator>Waast, Denis</creator><creator>Gaborit, Benjamin</creator><creator>Dauty, Marc</creator><creator>Deslandes, Guillaume</creator><creator>Dailly, Eric</creator><creator>Touchais, Sophie</creator><creator>Boutoille, David</creator><creator>Grégoire, Nicolas</creator><creator>Couet, William</creator><general>American Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1232-5761</orcidid><orcidid>https://orcid.org/0000-0002-6076-9722</orcidid><orcidid>https://orcid.org/0000-0001-9726-3082</orcidid><orcidid>https://orcid.org/0000-0002-5400-335X</orcidid><orcidid>https://orcid.org/0000-0001-6436-3757</orcidid><orcidid>https://orcid.org/0000-0002-7116-8965</orcidid></search><sort><creationdate>20180401</creationdate><title>Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery</title><author>Grégoire, Matthieu ; Libois, Julia Brochard ; Waast, Denis ; Gaborit, Benjamin ; Dauty, Marc ; Deslandes, Guillaume ; Dailly, Eric ; Touchais, Sophie ; Boutoille, David ; Grégoire, Nicolas ; Couet, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a478t-db36c310068aafec4949cc76b36168eccfc6c0a723462a3a17074da7ab84b64b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bariatric Surgery</topic><topic>Life Sciences</topic><topic>Obesity</topic><topic>Oxazolidinones</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology</topic><topic>Tetrazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grégoire, Matthieu</creatorcontrib><creatorcontrib>Libois, Julia Brochard</creatorcontrib><creatorcontrib>Waast, Denis</creatorcontrib><creatorcontrib>Gaborit, Benjamin</creatorcontrib><creatorcontrib>Dauty, Marc</creatorcontrib><creatorcontrib>Deslandes, Guillaume</creatorcontrib><creatorcontrib>Dailly, Eric</creatorcontrib><creatorcontrib>Touchais, Sophie</creatorcontrib><creatorcontrib>Boutoille, David</creatorcontrib><creatorcontrib>Grégoire, Nicolas</creatorcontrib><creatorcontrib>Couet, William</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grégoire, Matthieu</au><au>Libois, Julia Brochard</au><au>Waast, Denis</au><au>Gaborit, Benjamin</au><au>Dauty, Marc</au><au>Deslandes, Guillaume</au><au>Dailly, Eric</au><au>Touchais, Sophie</au><au>Boutoille, David</au><au>Grégoire, Nicolas</au><au>Couet, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>62</volume><issue>4</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC
) was 28.3 mg/liter · h. The AUC
/MIC ratio for unbound concentrations and for sensitive
and
strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>29378714</pmid><doi>10.1128/AAC.02432-17</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-1232-5761</orcidid><orcidid>https://orcid.org/0000-0002-6076-9722</orcidid><orcidid>https://orcid.org/0000-0001-9726-3082</orcidid><orcidid>https://orcid.org/0000-0002-5400-335X</orcidid><orcidid>https://orcid.org/0000-0001-6436-3757</orcidid><orcidid>https://orcid.org/0000-0002-7116-8965</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bariatric Surgery Life Sciences Obesity Oxazolidinones Pharmaceutical sciences Pharmacology Tetrazoles |
| title | Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery |
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