Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery

Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery

An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC ) was 28.3 mg/liter · h. The AUC /MIC rati...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2018-04, Vol.62 (4)
Hauptverfasser: Grégoire, Matthieu, Libois, Julia Brochard, Waast, Denis, Gaborit, Benjamin, Dauty, Marc, Deslandes, Guillaume, Dailly, Eric, Touchais, Sophie, Boutoille, David, Grégoire, Nicolas, Couet, William
Format: Artikel
Sprache:eng
Schlagworte:
Bariatric Surgery
Life Sciences
Obesity
Oxazolidinones
Pharmaceutical sciences
Pharmacology
Tetrazoles
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Zusammenfassung:An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC ) was 28.3 mg/liter · h. The AUC /MIC ratio for unbound concentrations and for sensitive and strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02432-17