Open-Label Pilot Study to Compare the Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5) Administered on an Early Alternative Dosing Schedule with Those of RV5 Administered on the Recommended Standard Schedule

Abstract This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5) administered on an alternative schedule (initiated at 2–5 weeks of age) with those of RV5 administered on the recommended standard schedule. Our findings support the future conduct of larger clinical tr...

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Veröffentlicht in:	Journal of the Pediatric Infectious Diseases Society 2018-02, Vol.7 (1), p.82-85
Hauptverfasser:	Saleh, Ezzeldin, Eichner, Brian, Clark, Douglas W, Gagliano, Martha E, Troutman, James M, Harrington, Lynn, McNeal, Monica, Clements, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Brief Reports Female Humans Immunization Schedule Infant Infant, Newborn Male Pilot Projects Rotavirus - immunology Rotavirus Infections - immunology Rotavirus Infections - prevention & control Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - adverse effects Rotavirus Vaccines - immunology Rotavirus Vaccines - therapeutic use Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology Vaccines, Attenuated - therapeutic use
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Beschreibung
Zusammenfassung:	Abstract This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5) administered on an alternative schedule (initiated at 2–5 weeks of age) with those of RV5 administered on the recommended standard schedule. Our findings support the future conduct of larger clinical trials to confirm the safety and efficacy of rotavirus vaccination in the neonatal period.
ISSN:	2048-7193 2048-7207
DOI:	10.1093/jpids/pix005