BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia

Little is known about the association of the BCL3-PVRL2-TOMM40 SNPs and dyslipidemia. This study was to detect 12 BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia in the Chinese Maonan population. Genotyping was performed in 1130 normal and 832 dyslipidemia partici...

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Veröffentlicht in:	Scientific reports 2018-04, Vol.8 (1), p.6189-11, Article 6189
Hauptverfasser:	Miao, Liu, Yin, Rui-Xing, Pan, Shang-Ling, Yang, Shuo, Yang, De-Zhai, Lin, Wei-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	45/41 45/43 45/77 692/4019/592/2727 692/699/75/2099 Alleles B-Cell Lymphoma 3 Protein Biomarkers China Dyslipidemia Dyslipidemias - etiology Dyslipidemias - metabolism Epistasis, Genetic Female Gene Frequency Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Genotype Genotype-environment interactions Genotypes Genotyping Haplotypes High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Life Style Linkage Disequilibrium Lipids - blood Male Membrane Transport Proteins - genetics Metabolic disorders Morbidity multidisciplinary Nectins - genetics Polymorphism Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Science Science (multidisciplinary) Single-nucleotide polymorphism Transcription Factors - genetics
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Zusammenfassung:	Little is known about the association of the BCL3-PVRL2-TOMM40 SNPs and dyslipidemia. This study was to detect 12 BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia in the Chinese Maonan population. Genotyping was performed in 1130 normal and 832 dyslipidemia participants. Generalized multifactor dimensionality reduction was used to screen the best interaction combination among SNPs and environmental exposures. Allele and genotype frequencies of the detected SNPs were different between the two groups ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-24432-w