Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro‐ and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism‐based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu. Hyperglycaemia‐induced oxidative stress drives pro‐inflammatory pathways to mediate end‐organ injury resulting in diabetic micro‐ and macrovascular complications. Targeting these downstream pathways is offering new avenues for therapeutic interventions to limit these debilitating complications.