Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients
Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis. Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilat...
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Veröffentlicht in: | International Journal of Pharmaceutical Investigation 2017-10, Vol.7 (4), p.188-192 |
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creator | Ravishankar, P Kumar, Y Anila, E Chakraborty, Priyankar Malakar, Maharshi Mahalakshmi, R |
description | Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis.
Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.
Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.
Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy. |
doi_str_mv | 10.4103/jphi.JPHI_82_17 |
format | Article |
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Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.
Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.
Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.</description><identifier>ISSN: 2230-973X</identifier><identifier>EISSN: 2230-9713</identifier><identifier>DOI: 10.4103/jphi.JPHI_82_17</identifier><identifier>PMID: 29692978</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Health aspects ; Original ; Patient compliance ; Periodontitis</subject><ispartof>International Journal of Pharmaceutical Investigation, 2017-10, Vol.7 (4), p.188-192</ispartof><rights>COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright: © 2018 International Journal of Pharmaceutical Investigation 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-c159f67030845fd48dca348708f1885b4bc9290ab02f50221a974b5898d33cf03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903023/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903023/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29692978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ravishankar, P</creatorcontrib><creatorcontrib>Kumar, Y</creatorcontrib><creatorcontrib>Anila, E</creatorcontrib><creatorcontrib>Chakraborty, Priyankar</creatorcontrib><creatorcontrib>Malakar, Maharshi</creatorcontrib><creatorcontrib>Mahalakshmi, R</creatorcontrib><title>Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients</title><title>International Journal of Pharmaceutical Investigation</title><addtitle>Int J Pharm Investig</addtitle><description>Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis.
Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.
Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.
Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.</description><subject>Health aspects</subject><subject>Original</subject><subject>Patient compliance</subject><subject>Periodontitis</subject><issn>2230-973X</issn><issn>2230-9713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1klFrFDEQx4MottQ--yYLvvhy12yye5u8CKVUWymooOCDMGSzyV3abLImux7203fObU8LmjwkTH7zn8nMEPKypMuqpPzketi45YdPF5cgGJTNE3LIGKcL2ZT86f7Ovx2Q45yvKa5KioatnpMDJleSyUYcku_n1ho9FtEWPmrlCzUM3mk1uhh2Rj0lPfUuFCp0RUzBdeo2elOsjS_QqjcpBqeLwSQXuxhGN7pcDOhuwphfkGdW-WyO788j8vXd-Zezi8XVx_eXZ6dXC10xPi50WUu7aiinoqptV4lOK16JhgpbClG3VasxW6paymxNGSuVbKq2FlJ0nGtL-RF5O-sOU9ubTmPspDwMyfUq_YKoHDx-CW4D6_gTaolBGUeBN_cCKf6YTB6hd1kb71UwccrAEJNY0KpB9PWMrpU34IKNqKh3OJzWCGDCK4nU8h8U7s70TsdgrEP7I4eT2UGnmHMydp99SWHXbdh1G_50Gz1e_f3pPf_QWwQ-z8A2-tGkfOOnrUmA7E2I2__pApYc5qGAaOH3UMDDUPA7EfvEXw</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Ravishankar, P</creator><creator>Kumar, Y</creator><creator>Anila, E</creator><creator>Chakraborty, Priyankar</creator><creator>Malakar, Maharshi</creator><creator>Mahalakshmi, R</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients</title><author>Ravishankar, P ; Kumar, Y ; Anila, E ; Chakraborty, Priyankar ; Malakar, Maharshi ; Mahalakshmi, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-c159f67030845fd48dca348708f1885b4bc9290ab02f50221a974b5898d33cf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Health aspects</topic><topic>Original</topic><topic>Patient compliance</topic><topic>Periodontitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ravishankar, P</creatorcontrib><creatorcontrib>Kumar, Y</creatorcontrib><creatorcontrib>Anila, E</creatorcontrib><creatorcontrib>Chakraborty, Priyankar</creatorcontrib><creatorcontrib>Malakar, Maharshi</creatorcontrib><creatorcontrib>Mahalakshmi, R</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Pharmaceutical Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ravishankar, P</au><au>Kumar, Y</au><au>Anila, E</au><au>Chakraborty, Priyankar</au><au>Malakar, Maharshi</au><au>Mahalakshmi, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients</atitle><jtitle>International Journal of Pharmaceutical Investigation</jtitle><addtitle>Int J Pharm Investig</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>7</volume><issue>4</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>2230-973X</issn><eissn>2230-9713</eissn><abstract>Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis.
Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.
Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.
Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>29692978</pmid><doi>10.4103/jphi.JPHI_82_17</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Health aspects Original Patient compliance Periodontitis |
title | Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients |
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