BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4

We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop...

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Veröffentlicht in:	Molecular biology of the cell 2018-04, Vol.29 (8), p.975-987
Hauptverfasser:	Ding, Baojin, Dobner, Paul R, Mullikin-Kilpatrick, Debra, Wang, Wei, Zhu, Hong, Chow, Chi-Wing, Cave, John W, Gronostajski, Richard M, Kilpatrick, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell Differentiation - genetics Cells, Cultured Cerebellum - growth & development Gene Expression Regulation, Developmental HEK293 Cells Humans Mice Mice, Inbred C57BL Mice, Knockout Neurons - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism NFI Transcription Factors - genetics NFI Transcription Factors - metabolism
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Zusammenfassung:	We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.
ISSN:	1059-1524 1939-4586 1939-4586
DOI:	10.1091/mbc.E16-08-0595