Membrane detachment is not essential for COG complex function

COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular biology of the cell 2018-04, Vol.29 (8), p.964-974
Hauptverfasser:	Climer, Leslie K, Pokrovskaya, Irina D, Blackburn, Jessica B, Lupashin, Vladimir V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - metabolism Glycosylation Golgi Apparatus - physiology HEK293 Cells Humans Membrane Proteins - metabolism Protein Subunits - metabolism Protein Transport Vesicular Transport Proteins - metabolism
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Beschreibung
Zusammenfassung:	COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.
ISSN:	1059-1524 1939-4586
DOI:	10.1091/mbc.E17-11-0694