17‐Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta‐analysis

Background Preterm birth complicates almost all triplet pregnancies and no preventive strategy has proven effective. Objective To determine, using individual patient data (IPD) meta‐analysis, whether the outcome of triplet pregnancy is affected by prophylactic administration of 17‐hydroxyprogesterone caproate (17OHPc). Search strategy We searched literature databases, trial registries and references in published articles. Selection criteria Randomised controlled trials (RCTs) of progestogens versus control that included women with triplet pregnancies. Data collection and analysis Investigators from identified RCTs collaborated on the protocol and contributed their IPD. The primary outcome was a composite measure of adverse perinatal outcome. The secondary outcome was the rate of birth before 32 weeks of gestation. Other pre‐specified outcomes included randomisation‐to‐delivery interval and rates of birth at