Alternative inflammasome activation enables IL-1β release from living cells

Alternative inflammasome activation enables IL-1β release from living cells

Highlights • Alternative NLRP3 inflammasome activation comprises a distinct signaling entity. • Genetic and phenotypic criteria distinguish alternative and classical NLRP3 signaling. • This includes absence of pyroptosis and GSDMD-independent IL-1β secretion.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in immunology 2017-02, Vol.44, p.7-13
Hauptverfasser: Gaidt, Moritz M, Hornung, Veit
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Caspase 8 - metabolism
Homeostasis
Humans
Inflammasomes - metabolism
Inflammation - immunology
Interleukin-1beta - metabolism
Lipopolysaccharides - immunology
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Potassium-Hydrogen Antiporters - metabolism
Pyroptosis
Signal Transduction
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Beschreibung
Zusammenfassung:Highlights • Alternative NLRP3 inflammasome activation comprises a distinct signaling entity. • Genetic and phenotypic criteria distinguish alternative and classical NLRP3 signaling. • This includes absence of pyroptosis and GSDMD-independent IL-1β secretion.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.10.007