PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma

Continuous activation of hypoxia-inducible factor (HIF) is important for progression of renal cell carcinoma (RCC) and acquired resistance to antiangiogenic multikinase and mTOR inhibitors. Recently, HIF2α antagonists PT2385 and PT2399 were developed and are being evaluated in a phase I clinical tri...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2017-11, Vol.77 (22), p.6321-6329
Hauptverfasser: Yoshino, Hirofumi, Nohata, Nijiro, Miyamoto, Kazutaka, Yonemori, Masaya, Sakaguchi, Takashi, Sugita, Satoshi, Itesako, Toshihiko, Kofuji, Satoshi, Nakagawa, Masayuki, Dahiya, Rajvir, Enokida, Hideki
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Sprache:eng
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