The impact of a dose of the angiotensin receptor blocker valsartan on post‐myocardial infarction ventricular remodelling

Aims Although clinical guidelines advocate the use of the highest tolerated dose of angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers after acute myocardial infarction (MI), the optimal dosing or the risk–benefit profile of different doses have not been fully identified. Meth...

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Veröffentlicht in:	ESC Heart Failure 2018-04, Vol.5 (2), p.354-363
Hauptverfasser:	Park, Kyungil, Kim, Young‐Dae, Kim, Ki‐Sik, Lee, Su‐Hoon, Park, Tae‐Ho, Lee, Sang‐Gon, Kim, Byung‐Soo, Hur, Seung‐Ho, Yang, Tae‐Hyun, Oh, Joo‐Hyun, Hong, Taek‐Jong, Park, Jong‐Sun, Hwang, Jin‐Yong, Jeong, Byungcheon, Bae, Woo‐Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - administration & dosage Clinical outcomes Dose Dose-Response Relationship, Drug Drug dosages Echocardiography Ejection fraction Electrocardiography Family medical history Female Follow-Up Studies Heart attacks Heart failure Heart Ventricles - diagnostic imaging Heart Ventricles - drug effects Heart Ventricles - physiopathology Humans Laboratories Male Middle Aged Myocardial infarction Original Original s Patients Population Retrospective Studies Single-Blind Method ST Elevation Myocardial Infarction - complications ST Elevation Myocardial Infarction - physiopathology ST Elevation Myocardial Infarction - therapy Stroke Volume - drug effects Stroke Volume - physiology Time Factors Treatment Outcome Valsartan Valsartan - administration & dosage Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling - drug effects Ventricular remodelling
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Zusammenfassung:	Aims Although clinical guidelines advocate the use of the highest tolerated dose of angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers after acute myocardial infarction (MI), the optimal dosing or the risk–benefit profile of different doses have not been fully identified. Methods and results In this multicentre trial, 495 Korean patients with acute ST segment elevation MI and subnormal left ventricular (LV) ejection fraction (
ISSN:	2055-5822 2055-5822
DOI:	10.1002/ehf2.12249