A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures

Breast cancer mortality predominantly results from dormant micrometastases that emerge as fatal outgrowths years after initial diagnosis. In order to gain insights concerning factors associated with emergence of liver metastases, we recreated spontaneous dormancy in an all-human ex vivo hepatic micr...

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Veröffentlicht in:	Molecular & cellular proteomics 2018-04, Vol.17 (4), p.619-630
Hauptverfasser:	Clark, Amanda M., Kumar, Manu P., Wheeler, Sarah E., Young, Carissa L., Venkataramanan, Raman, Stolz, Donna B., Griffith, Linda G., Lauffenburger, Douglas A., Wells, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Computer applications Dormancy Emergence Epidermal growth factor Female Hepatocytes Humans Inflammation Lipopolysaccharides Liver Liver - metabolism Liver - pathology Male Metastases Metastasis Nodules Signaling Tumor cells Tumors
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Beschreibung
Zusammenfassung:	Breast cancer mortality predominantly results from dormant micrometastases that emerge as fatal outgrowths years after initial diagnosis. In order to gain insights concerning factors associated with emergence of liver metastases, we recreated spontaneous dormancy in an all-human ex vivo hepatic microphysiological system (MPS). Seeding this MPS with small numbers (
ISSN:	1535-9476 1535-9484 1535-9484
DOI:	10.1074/mcp.RA117.000370