Central congenital hypothyroidism caused by maternal thyrotoxicosis

Central congenital hypothyroidism caused by maternal thyrotoxicosis

Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves’ disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disruption of fetal hypothalamic-pituitary-thyroid axis...

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Veröffentlicht in:BMJ case reports 2018-03, Vol.2018, p.bcr-2017-222620
Hauptverfasser: Peeters, Daphne, van Gijlswijk, Sandra, Leunissen, Ralph W., van der Kaay, Danielle C.M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Babies
Birth weight
Case reports
Congenital diseases
Congenital Hypothyroidism - blood
Congenital Hypothyroidism - diagnosis
Congenital Hypothyroidism - drug therapy
Diagnosis, Differential
Female
Humans
Hyperthyroidism
Hypothyroidism
Immunoglobulins
Infant, Newborn
Laboratories
Medical screening
Mutation
Newborn babies
Patients
Pediatrics
Postnatal Care
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - diagnosis
Rare Disease
Thyroid diseases
Thyrotoxicosis - blood
Thyrotoxicosis - diagnosis
Thyroxine - therapeutic use
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Beschreibung
Zusammenfassung:Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves’ disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disruption of fetal hypothalamic-pituitary-thyroid axis maturation. In CCH, maternal thyroid disease should be considered.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2017-222620