PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, i...

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Veröffentlicht in:	International journal of molecular sciences 2018-03, Vol.19 (3), p.913
Hauptverfasser:	Palomer, Xavier, Barroso, Emma, Pizarro-Delgado, Javier, Peña, Lucía, Botteri, Gaia, Zarei, Mohammad, Aguilar, David, Montori-Grau, Marta, Vázquez-Carrera, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Diabetes mellitus Diabetes mellitus (non-insulin dependent) Energy balance Energy metabolism Fatty liver Homeostasis Liver Liver diseases Metabolic disorders Metabolism Peroxisome proliferator-activated receptors Pharmacology Review Therapeutic applications
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Beschreibung
Zusammenfassung:	Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms19030913