Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study
Recently, 2 transcriptome-wide studies identified 40 genes that were differentially expressed in relation to blood pressure. However, to what extent these BP-related gene expression signatures and their associations with BP are driven by genetic or environmental factors has not been investigated. In...
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Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2018-03, Vol.71 (3), p.457-464 |
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Sprache: | eng |
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Zusammenfassung: | Recently, 2 transcriptome-wide studies identified 40 genes that were differentially expressed in relation to blood pressure. However, to what extent these BP-related gene expression signatures and their associations with BP are driven by genetic or environmental factors has not been investigated. In this study of 391 twins (193 twin pairs and 5 singletons; age 55–69 years; 40% male; 57% monozygous) recruited from the Finnish Twin Cohort, transcriptome-wide data on peripheral leukocytes were obtained using the Illumina HT12 V4 array. Our transcriptome-wide analysis identified 1 gene (MOK [MAPK/MAK/MRK overlapping kinase], P=7.16×10) with its expression levels associated with systolic BP at the cutoff of false-discovery rate |
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ISSN: | 0194-911X 1524-4563 1524-4563 |
DOI: | 10.1161/HYPERTENSIONAHA.117.10527 |