Answering Schrödinger's question: A free-energy formulation

The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay. The aim of this review is to synthesise these advances with a meta-theoretical ontology of biological systems called variational neuroethology, which integrates the FEP with Tinbergen's four research questions to explain biological systems across spatial and temporal scales. We exemplify this framework by applying it to Homo sapiens, before translating variational neuroethology into a systematic research heuristic that supplies the biological, cognitive, and social sciences with a computationally tractable guide to discovery. •We describe a meta-theoretical ontology of life based on the free energy principle.•We propose a multiscale formulation of the free energy principle.•We translate our ontology into a systematic research heuristic for life sciences.•We apply this meta-theoretical ontology and research heuristic to Homo sapiens.